The classic Halpern/Mulvany style wire myograph is back as a standard product available from Living Systems Instrumentation. Our MYO-CH wire myograph chamber is faithful to the basic design first introduced by Living Systems Instrumentation founder, the late Professor William Halpern, and Professor Michael Mulvany in their classic 1976 Nature paper titled “Mechanical properties of vascular smooth muscle cells in situ” (Nature 260(5552): 617-619, 1976). At the same time, state-of-the-art materials, machining, and force technology have been introduced. Our wire myographs include three types of tissue supports: wire-mounts for microvessels, L-bars for large ring preparations, and a hook for working with strips. Thus, our myograph is suitable for a range of applications including force measurements in microvessel rings, large vessels such as carotid artery and aorta, airway, intestine, bladder, and many more.