Learn how to study flow-mediated dilation and shear stress in pressurized arteries

Our recent webinar features useful information for users interested in studying flow-mediated dilations and the effects of shear stress on isolated resistance arteries.

 

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The physiological significance and effects of shear stress on controlling and coordinating vascular function are well-appreciated.  However, flow-mediated regulation of vascular function is a complex and difficult mechanism to study experimentally. Care must be taken to select appropriate instrumentation to allow for precise control of intravascular pressure and intraluminal flow, while minimizing artifacts introduced by the small size of glass cannulae. With proper simultaneous control of intravascular pressure and intraluminal flow, the researcher will be able to explore such responses as flow-mediated dilation, flow-induced constriction and other physiological responses that depend upon shear stress in the vasculature.

 

 

During this webinar Dr. Éric Thorin, a leading expert in the effects of shear stress in the vasculature, explains key concepts in setting up a system for the purpose of examining flow-mediated responses in isolated blood vessels.  Viewers will gain an understanding of how to setup and utilize a pressure arteriograph capable of simultaneous control of intravascular pressure and intraluminal flow.

 

Topics Covered:

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  • Required equipment
  • How to setup and calibrate instruments
  • Best practices, including how to minimize cannulae resistance
  • Sample experimental protocols and applications

 

View the webinar content by Clicking Here to access our Learning Resources section of the website.