Applications

Over 550 papers have been published using Living System Instrumentation's cannulated blood vessel system. We have compiled a bibliography, which may be accessed by clicking Bibliography.  Available in Adobe Acrobat for search use.

 A Host of Applications using these tools are at the disposal of the research investigator interested in obtaining new insights into the mechanisms of vascular function in human health and disease.

Typical Examples -

Studies: hypertension, diabetes, aging, and pregnancy

Tissue Sources: humans, primates, swine, rats, dogs, and rabbits

Vascular Beds: cerebral, coronary, lung, skin, and kidney

Vasoactive Agents: NO, endothelin, estrogen, peptides, and oxygen

Simultaneous Measurements: Fluorescence & Vessel Diameter

 

 

{short description of image}

Changes in diameter of rat gracilis arterioles as a function of perfusate flow

From: Koller A, Sun D, Huang A, Kaley G

Co-release of nitric oxide and prostaglandins mediates flow-dependent dilation of gracilis muscle arterioles. Am J Physiol 1994; 267:H326-H33

 

{short description of image}

Depolarization and constriction of rat myogenic cerebral arteries with tone by the KCA channel inhibitor iberiotoxin

From: Nelson MT , Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Lederer WJ

Relaxation of arterial smooth muscle by calcium sparks. Science 1995;270:633-637

Pressure = 60 mmHg


{short description of image}

Coronary microvessel responses of normal and atherosclerotic monkeys to acetylcholine

Vessel diameters = 122 - 220 µm

From: Sellke FW, Armstrong ML, Harrison DG

Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circ 1990;81:1586-1593

 

{short description of image}

Spontaneous vasomotion of cerebral artery diameter as a function of temperature

Pressure = 80 mmHg

From: Osol G, Halpern W

Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats. Am J Physiol 1988;254 (Heart Circ Physiol 23):H28-H33


{short description of image}

Oxygen reactivity of an isolated rat cremaster muscle arteriole

Pressure = 65 mmHg; ID = 77 µm

From: Messina EJ, Sun D, Koller A, Wolin MS, Kaley G

Increases in oxygen tension evoke arteriolar constriction by inhibiting endothelial prostaglandin synthesis. Microvasc Res 1994;48(2):151-160